Question 1

What is GLP-1 titration?

Accepted Answer

Titration means starting at a low dose and gradually increasing it over several weeks. This lets your body adjust to the medication and reduces side effects like nausea.

Question 2

How do you follow a titration schedule?

Accepted Answer

Stay at each dose level for the recommended number of weeks before moving up. Most protocols increase the dose every 4 weeks. Don't skip ahead, even if you feel fine.

Question 3

What happens if you skip a GLP-1 dose?

Accepted Answer

If you miss a dose and it's been less than 5 days, take it as soon as you remember. If more than 5 days have passed, skip it and take the next scheduled dose. Don't double up.

Question 4

What's the difference between semaglutide and tirzepatide titration?

Accepted Answer

Semaglutide (Ozempic/Wegovy) targets GLP-1 only and starts at 0.25 mg weekly. Tirzepatide (Mounjaro/Zepbound) targets both GLP-1 and GIP, starting at 2.5 mg weekly. Tirzepatide has more dose steps.

Question 5

Are titration schedules the same for compounded versions?

Accepted Answer

Compounded versions use the same active ingredient, so the titration timeline is similar. However, compounded peptides are dosed in mcg rather than mg. Always verify your concentration before drawing.

GLP-1 Titration Protocols

Semaglutide (Ozempic/Wegovy)

Tirzepatide (Mounjaro/Zepbound)

Retatrutide (Triple G)

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