Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20268 Citations
Semaglutide30 residuesHEGTFTSDVSSYLEGQAAKEFIAWLVRGRGEach bubble = one amino acid. Size = residue mass. Color = chemical class.Semaglutide holds four FDA approvals for obesity, type 2 diabetes, and cardiovascular risk reduction. STEP 1 confirmed 14.9% mean weight loss at 68 weeks. The 7.2 mg high-dose version (March 2026) pushes that to 20.7%. GI side effects are real but manageable with slow titration.
250mcg · Weekly
Summary: Add 2mL BAC water to your 5mg vial. Draw to 10.0 units on a U-100 syringe for a 250mcg dose. This vial will last 20 doses.
View side effects and safety warnings →
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 250mcg | Weekly |
| Moderate | 500mcg | Weekly |
| Aggressive | 1mg | Weekly |
Semaglutide ships in pre-filled brand pens (Wegovy, Ozempic, Wegovy HD) that require no reconstitution. For compounded vials, the math matters. 5 mg vial reconstituted with 2 mL bacteriostatic water = 2,500 mcg/mL. On a 100-unit insulin syringe, each unit equals 25 mcg. So your 250 mcg starting dose is 10 units; 500 mcg is 20 units; 1,000 mcg is 40 units; 2,400 mcg maintenance is 96 units. 10 mg vial in 2 mL = 5,000 mcg/mL. Each unit equals 50 mcg. Starting dose of 250 mcg is 5 units; 500 mcg is 10 units; 1,000 mcg is 20 units; 2,400 mcg is 48 units. Titrate slowly. Four weeks at each dose level is the FDA minimum, but experienced users commonly hold 6 to 8 weeks per step. Rushing the titration is the single most common beginner mistake; it makes nausea worse and does not speed up weight loss. You can always stay at a lower dose if appetite suppression is sufficient. Refrigerate compounded vials at 2 to 8 degrees Celsius and use within 6 weeks of reconstitution.
Dosing based on Wegovy FDA Prescribing Information (2024) — 12 published references.View all sources →
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Physician & Longevity Specialist
39% of weight loss was lean mass — resistance training is essential alongside GLP-1 therapy.
Naturopathic Doctor & Conservative Dosing Advocate
Dose up to appetite control, not suppression. Interventions are scaffolding, not crutches.
Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
Semaglutide holds four FDA approvals for obesity, type 2 diabetes, and cardiovascular risk reduction. STEP 1 confirmed 14.9% mean weight loss at 68 weeks. The 7.2 mg high-dose version (March 2026) pushes that to 20.7%. GI side effects are real but manageable with slow titration.
